The conversion of deutero-N15 tryptophan to quinolinic acid by the rat.
نویسندگان
چکیده
Quinolinic acid (pyridine-cr , /3-dicarboxylic acid) has been isolated from rat urine after administration of tryptophan to rats (1). It has been suggested that quinolinic acid is formed via 3-hydroxyanthranilic acid by oxidative cleavage of the benzene ring in the 3-4 position, followed by closure incorporating the amino nitrogen in a pyridine ring (1). In this paper are reported the results of studies of the formation of quinolinic acid from tryptophan labeled in the indole ring with N15 and in the benzene ring with deuterium.
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 195 2 شماره
صفحات -
تاریخ انتشار 1952